HUMAN CLINICAL ARTICLE Umbilical Cord-Derived Mesenchymal Stromal Cells (MSCs) for Knee Osteoarthritis: Repeated MSC Dosing Is Superior to a Single MSC Dose and to Hyaluronic Acid in a Controlled Randomized Phase I/II Trial JOSE MATAS | a MARIO ORREGO | a DIEGO AMENABAR | a CATALINA INFANTE | b RAFAEL TAPIA-LIMONCHI | b,c MARIA IGNACIA CADIZ | b FRANCISCA ALCAYAGA-MIRANDA | b,c,d PAZ L. GONZÁLEZ | d EMILIO MUSE | e MAROUN KHOURY | b,c,d FERNANDO E. FIGUEROA  | c,d,f FRANCISCO ESPINOZA b,c,f Key Words: Osteoarthritis • Knee • Mesenchymal stromal cells • Pain • Disability

European Journal of Orthopaedic Surgery & Traumatology https://doi.org/10.1007/s00590-020-02630-5 ORIGINAL ARTICLE Umbilical cord‐derived mesenchymal stem cells for treating osteoarthritis of the knee: a single‐arm, open‐label study Ismail Hadisoebroto Dilogo1,2,3 · Anissa Feby Canintika1· Alberto Lastiko Hanitya1 ·Jeanne Adiwinata Pawitan2,3,4 · Isabella Kurnia Liem2,3,5 · Jacub Pandelaki6 Received: 31 October 2019 / Accepted: 20 January 2020 © Springer-Verlag France SAS, part of Springer Nature 2020

Am J Transl Res 2021;13(2):448-461 www.ajtr.org /ISSN:1943-8141/AJTR0115060 Review Article Mesenchymal stem cells in osteoarthritis therapy: a review Chongtao Zhu1*, Wei Wu2*, Xiaowen Qu1 1Laser Medical Center, The First People’s Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, No. 157 Jinbi Road, Kunming 650032, Yunnan, China; 2College of Food Science and Engineering, Qingdao Agricultural University, No. 700 Changcheng Road, Qingdao 266109, Shandong, China. *Co-first authors. Received May 27, 2020; Accepted December 11, 2020; Epub February 15, 2021; Published February 28, 2021

Hindawi Stem Cells International Volume 2018, Article ID 3057624, 12 pages https://doi.org/10.1155/2018/3057624 Review Article Mesenchymal Stem Cell-Based Immunomodulation: Properties and Clinical Application Mengyuan Wang , Quan Yuan , and Liang Xie State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China Correspondence should be addressed to Quan Yuan; yuanquan@scu.edu.cn and Liang Xie; lxie@scu.edu.cn Received 26 March 2018; Accepted 29 May 2018; Published 14 June 2018 Academic Editor: Bo Yu Copyright © 2018 Mengyuan Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Research Article Efficacy of Intra-Articular Injection of Platelet-Rich Plasma Combined with Mesenchymal Stem Cells in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-Analysis Weipeng Zeng,1 Gongze Wang,2 Xinping Liao,1 and Caifeng Pei 3 1. Department of Joint Surgery, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou 570311, China 2. Department of Sports Medicine, Qionghai People’s Hospital, Qionghai 571400, China 3. Department of Orthopedics, People’s Hospital of Wanning Hainan, Hainan 571500, China

Tiềm năng của tế bào gốc trung mô trong điều trị thoái hoá khớp gối Mesenchymal Stem Cell-Based Immunomodulation: Properties and Clinical Application (2018) Mesenchymal stem cells in osteoarthritis therapy: a review (2021) Efficacy of Intra-Articular Injection of Platelet-Rich Plasma Combined with Mesenchymal Stem Cells in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-Analysis (2022)