Nguyen Hai Nam

Expertise:

• Research on the application of stem cells in treating disease and in rejuvenation
• Cancer screening

Career:

• General Director, MSC Vietnam Technology Investment and Development Joint Stock Company (present)
• Director, Mescells Institute of Applied Cell Technology Research (12/2020 – present)
• Lecturer, Nguyen Tat Thanh University (2019 – present)
• Head of Representative Office and Deputy Director for Professional Affairs and Technology, Life Science Development Co., Ltd. (2018 – 12/2020)
• Senior Advisor to the VGCT project – CT Group
• Researcher in stem cells, cell biology, molecular biology and animal disease models at the Stem Cell Institute, University of Science, Vietnam National University Ho Chi Minh City (2012 – 2018)

Education and training:

• Master’s degree in Experimental Biology (animal physiology), University of Science, Vietnam National University Ho Chi Minh City (2013 – 2017)
• Bachelor’s degree in Biology (animal physiology), University of Science, Vietnam National University Ho Chi Minh City (2008 – 2012)

Research projects:

• Principal investigator of the project “Research on the use of allogeneic umbilical cord tissue-derived mesenchymal stem cells in the treatment of knee osteoarthritis”, Ethics Committee in Biomedical Research, Dinh Tien Hoang Institute of Medicine (5/2023 – 10/2024).
• Member of the project “Experimental treatment of cirrhosis in a CCl4-induced cirrhotic mouse model using stem cell therapy”, Vietnam National University Ho Chi Minh City (2012 – 2015).
• Principal investigator of the project “Research on the efficacy in treating cirrhosis in mice of adipose-derived mesenchymal stem cells (hAD-MSC) cultured in medium containing platelet-rich plasma (PRP) and hepatocyte growth factor (HGF)”, Ho Chi Minh City Department of Science and Technology (2017 – 2018).
• Member of the project “Research on the role of autophagy and autophagy inhibitors in the activation of stellate cells in vitro and in vivo, to understand and explain the pathological mechanism of cirrhosis”, Ministry of Science and Technology (2017 – 2020)

Published research:

Co-inventor:

Granted Utility Solution Patent No. 2293: A process for differentiating adipose-derived mesenchymal stem cells into hepatocytes.

Papers published in international journals:

• Truong Hai Nhung, Nguyen Hai Nam, Nguyen Thi Kim Nguyen, Le Minh Huy, Tran Huong Giang, Huynh Nghia, Nguyen Van Thanh, Establishment of a standardized mouse model of hepatic fibrosis for biomedical research, Biomedical Research and Therapy, 1(2):43-49, 2014.
• Nhung TH, Nam NH, Nguyen NT, Nghia H, Van Thanh N, Ngoc PK, Van Pham P: A comparison of the chemical and liver extract-induced hepatic differentiation of adipose derived stem cells. In vitro cellular & developmental biology Animal 2015, 51(10):1085- 1092.
• Nhung Truong Hai, Nam Nguyen Hai, Trinh Le Van, Ngoc Vu, Huynh Nghia, Thanh Nguyen Van, Huy Le Minh, Kim Phan N, Phuc Van Pham. Comparisonofthe Treatment Efficiency of Bone Marrow-Derived Mesenchymal StemCell Transplantation via Tail and Portal Veins in CCl4-Induced MouseLiverFibrosis. Stem Cells Int, 2016. 2016: p.5720413.
• Nam Hai Nguyen, Trinh Van Le, Huy Quang Do, Dat Quoc Ngo, Huy Minh Le, Nhung Hai Truong, Comparative treatment efficiency of adipose and bone marrow derived allogenic mesenchymal stem cell transplantation in mouse models of liver fibrosis, Biomedical research and therapy, 2017, 4(6), 1374-1387.
• Trinh Van Le, Nam Hai Nguyen, Huy Quang Do, Huy Minh Le, Nhung Hai Truong, Transplantation of umbilical cord bloodderived mesenchymal stem cells to treat liver cirrhosis in mice: a comparison of tail and portal vein injection, Prog Stem Cell, 2017, 4(2): 201-216.
• Nam H. Nguyen, Trinh V. Le, Huy Q. Do, Thanh M. Dang, Ngoc H. Vo, Yen K T Nguyen, Nhung H.Truong. Human adipose-derived stem cells pretreated with platelet rich plasma and hepatocyte growth factor alleviate liver fibrosis in mice, Biomedical research and therapy, 2018.

Papers published in domestic journals:

• Nguyen Thi Kim Nguyen, Truong Hai Nhung, Nguyen Hai Nam, Pham Van Phuc, Phan Kim Ngoc. A survey of the in vitro differentiation of human adipose-derived mesenchymal stem cells into hepatocyte-like cells. Journal of Biology (Vietnam) 2014, 36 (1se): 209-215.
• Nguyen Hai Nam, Truong Hai Nhung, Le Van Trinh, Phan Van Tien, Le Minh Huy, Huynh Nghia, Nguyen Van Thanh, Phan Kim Ngoc, Pham Van Phuc. Evaluation of the effects of umbilical cord blood mesenchymal stem cell transplantation in a mouse model. VNU Journal of Science: Natural Sciences and Technology, Vol. 30, No. 6S (2014): 780-787.
• Le Van Trinh, Nguyen Hai Nam, Truong Hai Nhung, Ngo Quoc Dat, Le Minh Huy, Huynh Nghia, Nguyen Van Thanh, Pham Van Phuc, Phan Kim Ngoc. Evaluation of the efficacy of bone marrow mesenchymal stem cell transplantation in treating cirrhosis in a mouse model. Vietnam Journal of Science and Technology. 4(4) 4. 2016.

Papers in international conference proceedings:

• Nguyen Thi Kim Nguyen, Truong Hai Nhung, Mai Thi Trang, Nguyen Hai Nam, Pham Van Phuc, Phan Kim Ngoc. Experimental research on evaluating differentiation ability of adipose-derived mesenchymal stem cells into hepatocyte like cells in vitro.The first gen and immunotherapy conference in Vietnam (2013). Conference proceedings, p. 178.
• Nhung Truong Hai, Nam Nguyen Hai, Trinh Le Van, Ngoc Bich Vu, Nghia Huynh, Thanh Nguyen Van, Huy Le Minh, Dat Quoc Ngo, Kim Phan Ngoc, Phuc Van Pham. Bone marrow derived mesenchymal stem cells transplantation ameliorates liver function in mouse model of CCL4-induced liver fibrosis: the comparision of different transplantation routes. The second gen and immunotherepy Conference (2015), Viet Nam. Conference proceedings, p. 118.
• Trinh Van Le, Nam Hai Nguyen, Ngoc Kim Phan, Phuc Pham Van, Nhung Truong Hai. Human umbilical cord lood mesenchymal stem cell in treatment liver cirrhosis: efficiency comparative of route transplantation study on mice model. The second gen and immunotherepy Conference (2015), Viet Nam. Conference proceedings, p. 163.
• Truong, N.H., N.H. Nguyen, T.V. Le, N.B. Vu, N. Huynh, T.V. Nguyen, H.M. Le, N.K. Phan, and P.V. Pham. Platelet rich plasma enhances adipose-derived mesenchymal stem cell therapeutic effects for liver cirrhosis in mice. Hepatology,64(S1):363-605(599A- 600A),Liver Meeting 2016, Boston.
• Yen Thi-Nguyen Kim, Nam Nguyen Hai, Trinh Van Le, Ngoc Hong Vo, Thanh Minh Dang, Huy Quang Do, Nhung Truong Hai .The efficiency of adipose-derived stem cell pretreated with hepatocyte growth factor and platelet rich plasma on a liver cirrhosis mouse model. Innovations in cancer research and regenerative medicine III(2017). Conference proceedings, p. 157.
• Ngoc Hong Vo, Trinh Van Le, Nam Nguyen Hai, Yen Thi-Nguyen Kim, Thanh Minh Dang, Huy Quang Do, Nhung Truong Hai. Effectiveness of human adipose-derived stem cell therapy pretreated with hepatocyte growth factor in liver fibrosis mouse models. Innovations in cancer research and regenerative medicine III(2017). Conference proceedings, p. 119.
• Nhung Truong Hai, Nam Nguyen Hai, Trinh Le Van, Nghia Huynh, Dat Quoc Ngo, Thanh Nguyen Van, Kim Phan Ngoc, Phuc Van Pham. Adipose-derived stem cells and platelet rich plasma ameliorate liver cirrhotic circumstance in CCl4-induced mice: a new approach for liver cirrhosis treatment. Innovations in cancer research and regenerative medicine III(2017) Conference proceedings, p. 136.
• Trinh Van Le, Nam Hai Nguyen, Huy Quang Do, Huy Minh Le, Nhung Hai Truong. Transplantation of umbilical cord blood-derived mesenchymal stem cells to treat liver cirrhosis in mice: a comparison of tail and portal vein injection. Innovations in cancer research and regenerative medicine III(2017) Conference proceedings, p. 111.
• Nhung Hai Truong, Nam Hai Nguyen, Trinh Van Le, Huy Minh Le, Nghia Huynh, Dat Quoc Ngo, Thanh Van Nguyen, Ngoc Kim Phan, Phuc Van Pham. Adipose-Derived Mesenchymal Stem Cell Therapy for Liver Cirrhosis in Mice. The 6th International Conference on the Development of Biomedical Engineering in Vietnam (BME6). BME 2017. IFMBE Proceedings, vol 63. Springer, Singapore.
• Huy Quang Do, Minh Thanh Dang, Nam Hai Nguyen, Trinh Van Le, Tien-Trieu Pham- Le, Luan Van Tran, Tuong-Vi Thi Pham, Vinh Xuan Dinh Nguyen, Khon Chan Huynh, Ai-Xuan Le Holterman, Nhung Hai Truong. Granulocyte colony-stimulating factor alleviates the pathological condition in bile duct ligation in mice. BME 2018.

Papers in domestic conference proceedings:

• Nguyen Thi Kim Nguyen, Truong Hai Nhung, Nguyen Hai Nam, Pham Van Phuc, Phan Kim Ngoc. A survey of the in vitro differentiation of human adipose-derived mesenchymal stem cells into hepatocyte-like cells. 3rd National Biotechnology Conference for the Southern Region, 2013, “Biotechnology for Life”. Conference proceedings, p. 147.
• Nguyen Hai Nam, Truong Hai Nhung, Le Van Trinh, Phan Van Tien, Le Minh Huy, Huynh Nghia, Nguyen Van Thanh, Phan Kim Ngoc, Pham Van Phuc. Evaluation of the effects of umbilical cord blood mesenchymal stem cell transplantation in a mouse model. 3rd Conference of Young Scientists in Natural Sciences and Technology, 2014, Hanoi University of Science. Conference proceedings, p. 72.
• Nguyen Hai Nam, Truong Hai Nhung, Le Van Trinh, Phan Van Tien. Research on establishing a CCl4-induced cirrhotic mouse model under PHENOBARBITAL induction. 9th Scientific Conference of the University of Science, 2014. Conference proceedings, p. 184.
• Nguyen Hai Nam, Le Van Trinh, Truong Hai Nhung. Application of adipose-derived mesenchymal stem cell therapy in treating cirrhosis in white mice. 10th Scientific Conference of the University of Science, 2016.
• Le Van Trinh, Nguyen Hai Nam, Truong Hai Nhung. Comparison of the efficacy in treating cirrhosis in mice of umbilical cord blood mesenchymal stem cell transplantation via the portal vein and a peripheral vein. 10th Scientific Conference of the University of Science, 2016.
• Le Van Trinh, Do Quang Huy, Dang Minh Thanh, Nguyen Hai Nam, Le Pham Tien Trieu, Tran Van Luan, Pham Thi Tuong Vi, Nguyen Pham Anh Hoa, Ai Xuan Le Holterman, Truong Hai Nhung. Effects of granulocyte colony-stimulating factor (G-CSF) on liver function in mice with bile duct obstruction. National Biotechnology Conference 2018.